a novel rationally designed lanthanoid chelating tag

[PDF] Single-armed phenylsulfonated pyridine derivative of a novel rationally designed lanthanoid chelating tag

Single-armed DOTA-like phenylsulfonated pyridine derivatives are rigid and stable paramagnetic tags for site-specific labeling of proteins. Their reactions with a solvent-exposed protein thiol group generate a stable C-S bond and produce one single paramagnetic species in solution NMR. The generated large paramagnetic effects yield valuable long-range structural restraints for proteins.[PDF] Design and applications of lanthanide chelating tags a novel rationally designed lanthanoid chelating tagA complete overview is presented of DOTA-derived and non-DOTA-derived lanthanide chelating tags, critical points in the design of lanthanide chelating tags as appropriate linker moieties, their stability under reductive conditions, e.g., for in-cell applications, the magnitude of the anisotropy transferred from the lanthanide chelating tag to the biomacromolecule under investigation and structural properties, as well as conformational bias of the lanthanide chelating tags Swiss Science Concentrates - CHIMIAA Novel, Rationally Designed Lanthanoid Chelating Tag Delivers Large Paramagnetic Structural Restraints for Biomolecular NMR D. Joss, F. Winter, and D. Häussinger,* Chem. Commun. 2020, 56, 1286112864. University of Basel The rigid immobilization of lanthanoid chelating tags (LCTs) on biomacromolecules induces large paramagnetic effects a novel rationally designed lanthanoid chelating tag

Subject: "carbonate dehydratase" - PubAg Search Results

A locked padlock) or https:// means youve safely connected to the .gov website. Share sensitive information only on official, secure websites.Some results are removed in response to a notice of local law requirement. For more information, please see here.Structural Origin of the High Affinity of a Chemically a novel rationally designed lanthanoid chelating tagD. Joss, R. Vogel, K. Zimmermann, D. Häussinger, Application of Paramagnetic Lanthanoid Chelating Tags in NMR Spectroscopy and Their Use for the Localization of Ligands Within Biomacromolecules, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 10.1016/B978-0-12-409547-2.14848-6, (2020).Rational design of lanthanide binding peptides - ScienceDirectJun 01, 2013 · The design of a novel pentadentate chelating amino acid Ed3a 2 and its insertion in P 22 sequence in place of one Ada 2 was particularly efficient: octadentate Tb 3+ complexes with impressive femtomolar stability were formed in water. The octadentate coordination provides totally dehydrated complexes with better luminescence properties.

Publications | Research Group Häussinger

"A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR." D. Joss, F. Winter, D. Häussinger, Chem. Commun., 2020, 56, 12861-12864. "Divergent Synthesis of Bioactive Dithiodiketopiperazine Natural Products Based on a Double C(sp 3)-H Activation Strategy."Prof. Dr. Daniel Häussinger | Research Group Häussinger"A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR." D. Joss, F. Winter, D. Häussinger, Chemical NMR Structure Determination of ProteinLigand Complexes Jan 10, 2007 · A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR. Chemical Communications 2020, 56 (84), 12861-12864. https://doi.org/10.1039/D0CC04337K Michele Invernici, Inês B. Trindade, Francesca Cantini, Ricardo O. Louro, Mario Piccioli.

Ligand-driven conformational changes of MurD visualized by a novel rationally designed lanthanoid chelating tag

Nov 19, 2015 · A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR Daniel Joss, Florine Winter & Daniel HäussingerIn-Cell Protein Structures from 2D NMR Experiments | The a novel rationally designed lanthanoid chelating tagA novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR. Chemical Communications 2020, 56 (84) , 12861-12864. https://doi.org/10.1039/D0CC04337K; Thomas Müntener, Raphael Böhm, Kenneth Atz, Daniel Häussinger, Sebastian Hiller.Development of a novel rationally designed antibiotic to a novel rationally designed lanthanoid chelating tag1. Can J Physiol Pharmacol. 2017 May;95(5):595-603. doi: 10.1139/cjpp-2016-0505. Epub 2017 Apr 20. Development of a novel rationally designed antibiotic to inhibit a nontraditional bacterial target.

Design, Synthesis, and Evaluation of a Lanthanide a novel rationally designed lanthanoid chelating tag

Oct 01, 2008 · A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR. Chemical Communications 2020, 56 (84) , 12861-12864.Cited by: 171Publish Year: 2008Author: Peter H. J. Keizers, Athanasios Saragliadis, Yoshitaka Hiruma, Mark Overhand, Marcellus UbbinkDesign and applications of lanthanide chelating tags for a novel rationally designed lanthanoid chelating tagA complete overview is presented of DOTA-derived and non-DOTA-derived lanthanide chelating tags, critical points in the design of lanthanide chelating tags as appropriate linker moieties, their stability under reductive conditions, e.g., for in-cell applications, the magnitude of the anisotropy transferred from the lanthanide chelating tag to a novel rationally designed lanthanoid chelating tagDaniel Joss | Research Group HäussingerPublications "A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR." D. Joss, F. Winter, D. Häussinger, Chemical Communications, 2020, 56, 12861-12864.

DOTA-M8: An Extremely Rigid, High-Affinity Lanthanide a novel rationally designed lanthanoid chelating tag

Sep 28, 2009 · A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR. Chemical Communications 2020 , 56 (84) , 12861-12864.Cited by: 138Publish Year: 2009Author: Daniel Häussinger, Jie-rong Huang, Stephan GrzesiekBrowse by Basel Contributors ID - edoc(2020) A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR. Chemical Communications , 56 (84). pp. 12673-12870 . Thesmar, Pierre and Coomar, Seemon and Prescimone, Alessandro and A sterically overcrowded, isopropyl-substituted lanthanide a novel rationally designed lanthanoid chelating tagA sterically overcrowded lanthanide chelating tag was synthesized in order to investigate the influence on the obtained pseudocontact shifts and the anisotropic part of magnetic susceptibility tensor, when compared to the predecessor DOTA-M8-(4R4S)-SSPy. For the first time, a concise synthetic route is presented for isopropyl-substituted cyclen, the macrocyclic scaffold of the lanthanide a novel rationally designed lanthanoid chelating tag

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